40 Powerful Prayer Points For Breakthrough With Scriptures

Introduction

What is a Breakthrough?

A breakthrough is a moment of triumph when barriers are broken, and victory is achieved. Whether it’s overcoming spiritual dryness, financial struggles, or emotional challenges, breakthroughs represent a shift toward God’s promises.

Why Prayer is Essential for Breakthroughs?

Prayer is one of the most powerful tools believers have to experience a breakthrough. It connects us with God’s infinite wisdom and power, enabling us to overcome life’s toughest obstacles. In James 5:16, we are reminded, “The prayer of a righteous person is powerful and effective.” When we pray, we align ourselves with God’s will, opening the door for His intervention.

The Role of Scripture in Prayers

As you read on, you’ll discover 40 powerful prayer points for breakthrough, carefully categorized to cover all areas of life. Each prayer point is paired with a Scripture to guide and strengthen your faith.

A. Prayers for Spiritual Breakthrough (10 Points)

1. Prayer for a closer relationship with God
Lord, I desire to draw closer to You. Help me seek Your face daily and abide in Your presence. Remove every distraction that hinders my relationship with You.
Scripture Reference: “Draw nigh to God, and he will draw nigh to you. Cleanse your hands, ye sinners; and purify your hearts, ye double minded.” (James 4:8 KJV)

2. Prayer for the renewal of the mind
Heavenly Father, renew my mind with Your Word. Let my thoughts align with Your truth, and guide me to focus on things that glorify You.
Scripture Reference: “And be not conformed to this world: but be ye transformed by the renewing of your mind, that ye may prove what is that good, and acceptable, and perfect, will of God.” (Romans 12:2 KJV)

3. Prayer for a fresh outpouring of the Holy Spirit
Holy Spirit, fill me anew with Your power and presence. Let my life be a reflection of Your grace and love.
Scripture Reference: “And it shall come to pass afterward, that I will pour out my spirit upon all flesh; and your sons and your daughters shall prophesy, your old men shall dream dreams, your young men shall see visions.” (Joel 2:28 KJV)

4. Prayer against spiritual dryness
Lord, revive me from spiritual dryness. Let Your living water flow through me and refresh my soul.
Scripture Reference: “For I will pour water upon him that is thirsty, and floods upon the dry ground: I will pour my spirit upon thy seed, and my blessing upon thine offspring.” (Isaiah 44:3 KJV)

5. Prayer for spiritual discernment
Father, grant me the ability to discern Your will and recognize the tactics of the enemy. Help me walk in wisdom and truth.
Scripture Reference: “That ye may approve things that are excellent; that ye may be sincere and without offence till the day of Christ.” (Philippians 1:10 KJV)

6. Prayer to overcome spiritual battles
Lord, strengthen me to stand firm in spiritual warfare. Equip me with Your full armor to defeat the plans of the enemy.
Scripture Reference: “Put on the whole armour of God, that ye may be able to stand against the wiles of the devil.” (Ephesians 6:11 KJV)

7. Prayer for boldness in faith
Father, give me the boldness to live out my faith and share the gospel with confidence.
Scripture Reference: “The wicked flee when no man pursueth: but the righteous are bold as a lion.” (Proverbs 28:1 KJV)

8. Prayer for God’s guidance
Lord, direct my steps according to Your perfect will. Lead me on the path of righteousness and purpose.
Scripture Reference: “The steps of a good man are ordered by the Lord: and he delighteth in his way.” (Psalm 37:23 KJV)

9. Prayer for spiritual hunger and thirst
Father, create in me a deep hunger and thirst for Your Word and presence. Satisfy my soul with Your truth.
Scripture Reference: “Blessed are they which do hunger and thirst after righteousness: for they shall be filled.” (Matthew 5:6 KJV)

10. Prayer for steadfastness in faith
Lord, help me remain steadfast in my faith, no matter the trials I face. Strengthen me to persevere and trust in You.
Scripture Reference: “Therefore, my beloved brethren, be ye stedfast, unmoveable, always abounding in the work of the Lord, forasmuch as ye know that your labour is not in vain in the Lord.” (1 Corinthians 15:58 KJV)

B. Prayers for Financial Breakthrough (10 Points)

1. Prayer for God’s provision
Heavenly Father, You are my provider. Supply all my needs according to Your riches in glory. I trust You to open doors of provision in my life.
Scripture Reference: “But my God shall supply all your need according to his riches in glory by Christ Jesus.” (Philippians 4:19 KJV)

2. Prayer for breaking financial curses
Lord, I renounce every curse of lack and poverty over my life. Let Your blessings overflow in my finances as I walk in obedience to Your Word.
Scripture Reference: “Bring ye all the tithes into the storehouse, that there may be meat in mine house, and prove me now herewith, saith the Lord of hosts, if I will not open you the windows of heaven, and pour you out a blessing, that there shall not be room enough to receive it.” (Malachi 3:10 KJV)

3. Prayer for wisdom in financial decisions
Father, grant me wisdom to manage my finances with integrity. Teach me to be a good steward of the resources You provide.
Scripture Reference: “Trust in the Lord with all thine heart; and lean not unto thine own understanding. In all thy ways acknowledge him, and he shall direct thy paths.” (Proverbs 3:5-6 KJV)

4. Prayer for open doors in business or career
Lord, open doors of opportunities in my career and business. Let favor surround me as I work diligently to fulfill my purpose.
Scripture Reference: “The Lord shall open unto thee his good treasure, the heaven to give the rain unto thy land in his season, and to bless all the work of thine hand: and thou shalt lend unto many nations, and thou shalt not borrow.” (Deuteronomy 28:12 KJV)

5. Prayer against poverty and lack
Father, break every chain of poverty and lack in my life. Bless me abundantly so I may also bless others.
Scripture Reference: “The young lions do lack, and suffer hunger: but they that seek the Lord shall not want any good thing.” (Psalm 34:10 KJV)

6. Prayer for debt cancellation
Lord, I place my debts in Your hands. Guide me to make wise decisions and provide the resources to clear my obligations.
Scripture Reference: “Owe no man any thing, but to love one another: for he that loveth another hath fulfilled the law.” (Romans 13:8 KJV)

7. Prayer for financial breakthrough in the family
Father, bless my family with financial stability. Let us always have enough to meet our needs and share with others.
Scripture Reference: “And God is able to make all grace abound toward you; that ye, always having all sufficiency in all things, may abound to every good work.” (2 Corinthians 9:8 KJV)

8. Prayer for protection over finances
Lord, protect the resources You’ve given me from loss, theft, and misuse. Let Your hand guard my financial blessings.
Scripture Reference: “The Lord shall preserve thy going out and thy coming in from this time forth, and even for evermore.” (Psalm 121:8 KJV)

9. Prayer for contentment
Father, teach me to be content with what I have while trusting You for greater blessings. Help me remain grateful and faithful in every season.
Scripture Reference: “But godliness with contentment is great gain.” (1 Timothy 6:6 KJV)

10. Prayer for generosity
Lord, give me a heart of generosity. As You bless me, help me to be a blessing to others and advance Your kingdom.
Scripture Reference: “Give, and it shall be given unto you; good measure, pressed down, and shaken together, and running over, shall men give into your bosom. For with the same measure that ye mete withal it shall be measured to you again.” (Luke 6:38 KJV)

SEE ALSO: 7 Days Fasting and Prayer for Financial Breakthrough

C. Prayers for Healing and Health Breakthrough (10 Points)

1. Prayer for physical healing
Lord, You are the Great Physician. I ask for Your healing touch upon my body. Restore me to perfect health according to Your Word.
Scripture Reference: “But he was wounded for our transgressions, he was bruised for our iniquities: the chastisement of our peace was upon him; and with his stripes we are healed.” (Isaiah 53:5 KJV)

2. Prayer for emotional healing
Heavenly Father, heal my broken heart and bind up my wounds. Fill me with Your peace and joy in place of pain.
Scripture Reference: “The Lord is nigh unto them that are of a broken heart; and saveth such as be of a contrite spirit.” (Psalm 34:18 KJV)

3. Prayer against generational sickness
Lord, I break every chain of generational sickness in my family. Let Your healing power flow through every generation.
Scripture Reference: “And said, If thou wilt diligently hearken to the voice of the Lord thy God, and wilt do that which is right in his sight, and wilt give ear to his commandments, and keep all his statutes, I will put none of these diseases upon thee, which I have brought upon the Egyptians: for I am the Lord that healeth thee.” (Exodus 15:26 KJV)

4. Prayer for strength during trials
Father, give me the strength to endure this season of illness. Help me to trust in Your plan and wait patiently for Your healing.
Scripture Reference: “But they that wait upon the Lord shall renew their strength; they shall mount up with wings as eagles; they shall run, and not be weary; and they shall walk, and not faint.” (Isaiah 40:31 KJV)

5. Prayer for restoration of health
Lord, restore my health completely and renew my strength. Let my healing be a testimony of Your goodness.
Scripture Reference: “For I will restore health unto thee, and I will heal thee of thy wounds, saith the Lord; because they called thee an Outcast, saying, This is Zion, whom no man seeketh after.” (Jeremiah 30:17 KJV)

6. Prayer for divine protection from sickness
Father, protect me and my loved ones from every form of illness and disease. Cover us with Your healing power.
Scripture Reference: “There shall no evil befall thee, neither shall any plague come nigh thy dwelling.” (Psalm 91:10 KJV)

7. Prayer for healing from chronic pain
Lord, relieve me from this chronic pain and discomfort. Let Your healing power touch the source of my affliction.
Scripture Reference: “And Jesus went about all Galilee, teaching in their synagogues, and preaching the gospel of the kingdom, and healing all manner of sickness and all manner of disease among the people.” (Matthew 4:23 KJV)

8. Prayer for peace amidst sickness
Father, grant me peace in the midst of my health challenges. Calm my spirit and reassure me of Your faithfulness.
Scripture Reference: “Thou wilt keep him in perfect peace, whose mind is stayed on thee: because he trusteth in thee.” (Isaiah 26:3 KJV)

9. Prayer for medical caregivers
Lord, bless and guide the hands of doctors, nurses, and caregivers who are attending to my needs. Give them wisdom and compassion.
Scripture Reference: “And the Lord shall guide thee continually, and satisfy thy soul in drought, and make fat thy bones: and thou shalt be like a watered garden, and like a spring of water, whose waters fail not.” (Isaiah 58:11 KJV)

10. Prayer for complete deliverance from sickness
Father, I declare complete deliverance from every sickness and disease in Jesus’ name. Let my life be a testimony of Your healing power.
Scripture Reference: “And ye shall serve the Lord your God, and he shall bless thy bread, and thy water; and I will take sickness away from the midst of thee.” (Exodus 23:25 KJV)

SEE ALSO: HOW TO PRAY FOR MEN: 30 PRAYER POINTS

D. Prayers for Family and Relationships (10 Points)

1. Prayer for family unity
Heavenly Father, bring unity and love into my family. Let us be bound together in peace and harmony, reflecting Your love to one another.
Scripture Reference: “Behold, how good and how pleasant it is for brethren to dwell together in unity!” (Psalm 133:1 KJV)

2. Prayer for peace in the home
Lord, fill my home with Your peace. Remove every spirit of conflict, and let Your presence reign in every corner of our lives.
Scripture Reference: “Thou wilt keep him in perfect peace, whose mind is stayed on thee: because he trusteth in thee.” (Isaiah 26:3 KJV)

3. Prayer for reconciliation
Father, mend broken relationships in my family. Help us to forgive one another and restore what has been lost.
Scripture Reference: “And be ye kind one to another, tenderhearted, forgiving one another, even as God for Christ’s sake hath forgiven you.” (Ephesians 4:32 KJV)

4. Prayer for godly wisdom in parenting
Lord, grant me wisdom to raise my children in Your ways. Help me to guide them with love, patience, and understanding.
Scripture Reference: “Train up a child in the way he should go: and when he is old, he will not depart from it.” (Proverbs 22:6 KJV)

5. Prayer for a godly spouse (if single)
Father, lead me to the spouse You have prepared for me. Let our relationship glorify You and be built on a solid foundation of faith.
Scripture Reference: “Whoso findeth a wife findeth a good thing, and obtaineth favour of the Lord.” (Proverbs 18:22 KJV)

6. Prayer for marital restoration
Lord, heal every area of my marriage that is broken. Strengthen our bond and help us to grow in love and respect for one another.
Scripture Reference: “What therefore God hath joined together, let not man put asunder.” (Matthew 19:6 KJV)

7. Prayer for protection over my family
Father, place a hedge of protection around my family. Keep us safe from harm, danger, and the plans of the enemy.
Scripture Reference: “The angel of the Lord encampeth round about them that fear him, and delivereth them.” (Psalm 34:7 KJV)

8. Prayer for financial stability in the family
Lord, bless my family with financial stability. Provide for all our needs and give us wisdom to manage our resources well.
Scripture Reference: “But my God shall supply all your need according to his riches in glory by Christ Jesus.” (Philippians 4:19 KJV)

9. Prayer for salvation of family members
Father, I pray for the salvation of every unsaved member of my family. Draw them closer to You and let them experience Your grace.
Scripture Reference: “Believe on the Lord Jesus Christ, and thou shalt be saved, and thy house.” (Acts 16:31 KJV)

10. Prayer for love and understanding
Lord, let love and understanding be the foundation of our family. Teach us to be patient, kind, and compassionate toward one another.
Scripture Reference: “Charity suffereth long, and is kind; charity envieth not; charity vaunteth not itself, is not puffed up.” (1 Corinthians 13:4 KJV)

E. Prayers for Breakthrough in Difficult Situations (10 Points)

1. Prayer for strength in trials
Lord, I ask for strength to endure and overcome every trial in my life. Help me to remain steadfast and trust in Your timing.
Scripture Reference: “My brethren, count it all joy when ye fall into divers temptations; Knowing this, that the trying of your faith worketh patience.” (James 1:2-3 KJV)

2. Prayer for deliverance from fear
Father, remove every fear from my heart and replace it with faith. Help me to walk boldly, knowing You are with me.
Scripture Reference: “For God hath not given us the spirit of fear; but of power, and of love, and of a sound mind.” (2 Timothy 1:7 KJV)

3. Prayer for guidance in tough decisions
Lord, guide me as I face difficult decisions. Let Your wisdom direct my path, and lead me according to Your will.
Scripture Reference: “If any of you lack wisdom, let him ask of God, that giveth to all men liberally, and upbraideth not; and it shall be given him.” (James 1:5 KJV)

4. Prayer for deliverance from bondage
Heavenly Father, break every chain of bondage in my life. Set me free from anything holding me back from Your purpose.
Scripture Reference: “If the Son therefore shall make you free, ye shall be free indeed.” (John 8:36 KJV)

5. Prayer for victory over enemies
Lord, fight my battles and grant me victory over every enemy that rises against me. Let Your power be evident in my life.
Scripture Reference: “No weapon that is formed against thee shall prosper; and every tongue that shall rise against thee in judgment thou shalt condemn. This is the heritage of the servants of the Lord, and their righteousness is of me, saith the Lord.” (Isaiah 54:17 KJV)

6. Prayer for hope and encouragement
Father, fill my heart with hope and encouragement. Help me to trust in Your promises even in the darkest moments.
Scripture Reference: “Why art thou cast down, O my soul? and why art thou disquieted in me? hope thou in God: for I shall yet praise him, who is the health of my countenance, and my God.” (Psalm 42:11 KJV)

7. Prayer for provision in difficult times
Lord, provide for my needs in this season of difficulty. Let me experience Your miraculous provision and faithfulness.
Scripture Reference: “But they that seek the Lord shall not want any good thing.” (Psalm 34:10 KJV)

8. Prayer for peace in the storm
Father, speak peace into every storm in my life. Calm my fears and help me to rest in Your promises.
Scripture Reference: “And he arose, and rebuked the wind, and said unto the sea, Peace, be still. And the wind ceased, and there was a great calm.” (Mark 4:39 KJV)

9. Prayer for resilience in adversity
Lord, give me the resilience to keep moving forward, no matter how tough the situation. Strengthen my spirit to endure.
Scripture Reference: “I can do all things through Christ which strengtheneth me.” (Philippians 4:13 KJV)

10. Prayer for God’s intervention
Heavenly Father, I call upon You to intervene in my situation. Do what only You can do, and turn my circumstances around.
Scripture Reference: “Call unto me, and I will answer thee, and shew thee great and mighty things, which thou knowest not.” (Jeremiah 33:3 KJV)

Conclusion: Trusting God for Your Breakthrough

Breakthroughs are not achieved by our strength but by placing our faith in God and relying on His Word. Through these prayer points for breakthrough, we align ourselves with God’s promises and invite His power into every area of our lives. As you pray, believe that God is faithful to His Word and will answer according to His perfect will.

Remember the words of Jesus:
“Therefore I say unto you, What things soever ye desire, when ye pray, believe that ye receive them, and ye shall have them.” (Mark 11:24 KJV)

Keep pressing forward in faith, stay rooted in the scriptures, and trust that God’s timing is always perfect. Your breakthrough is on the way—stand firm, be persistent, and give thanks in advance for what the Lord is about to do in your life.